Jay Leno has always been the man who could make a room laugh with just a raised eyebrow or a perfectly timed joke. But in recent years, the former Tonight Show host has faced something no humor can ease: his wife Mavis’ fight with advanced dementia. The diagnosis became public in 2024, along with the news that Leno had been granted conservatorship to manage her care, protect her estate, and make major decisions on her behalf.